APOE and Hypercholesterolemia: In an in vivo model, Alkemade et al. [23] demonstrated that both in utero programming and diet-induced hypercholesterolemia affected histone methylation modifications and expression of accompanying lysine methyltransferases in vascular EC and SMC, in 20-week old female apoE+/− mouse offspring from apoE−/− and wild-type mothers.Furthermore, these epigenetic modifications were different in each cell type, which suggest cell-specific epigenetic effects in response to a similar stimuli [23].