Secretion of MMP-28 into conditioned media as a furin-cleaved protein (Mr-48 kDa) has been reported with human HT1080 fibrosarcoma, HeLa cervical cancer cells and A549 lung adenocarcinoma cells transfected with mouse MMP-28 cDNA [29, 39, 44]. The gene discussed is FURIN; the disease is lung adenocarcinoma.