Interestingly, translocations occur in the NPM1 N-terminal region where it fuses to different partner genes, such as anaplastic lymphoma kinase (ALK), retinoic acid receptor α (RARα), or myeloid leukemia factor 1 (MLF1) in ALCL, APL and MDS respectively. The gene discussed is NPM1; the disease is acute promyelocytic leukemia.