Increased MUC2 mRNA was noted by quantitative RT-PCR analysis in human colon cancer cell lines in response to a single stimulation with IL-4 (approximate two-fold increase in comparison to baseline), IL-13, and TNF-α (c.2.5-fold increase in MUC2 mRNA) via MAP kinase pathways [30]. Here, IL4 is linked to malignant colon neoplasm.