Interestingly, fusions of CLTC with the anaplastic lymphoma kinase (ALK) have been encountered in inflammatory myofibroblastic tumors and anaplastic large-cell lymphomas [10], whereas fusions with the transcription factor TFE3 have been encountered in renal cell carcinomas (RCC) [11], [12]. The gene discussed is CLTC; the disease is hereditary clear cell renal cell carcinoma.