On the other hand, non-cytolytic mechanisms of viral control involving reduced infectivity or reduced production of virus are consistent with the experimental data from SHIV vaccination analyzed here, as well as the results from CD8-depletion experiments and immune escape kinetics in SIV/SHIV-infected macaques ([14], [15], [16]), suggesting that further work is required to elucidate the cellular and molecular mechanisms by which vaccine-induced CD8+ T cells can control HIV infection. Here, CD8A is linked to HIV infectious disease.