For example, associations have been found between aUPD and homozygous mutations: in c-CBL in acute myeloid leukemia and atypical chronic myeloid leukemia [17], [18]; in JAK2 and myeloproliferative disorders [2], [19]; in NF-1 and juvenile myelomonocytic leukemia [20]; in A20 and B-cell lymphoma [10], and in TET and myelodysplastic syndrome [3], [11], in MPL and refractory anemia with ringed sideroblasts and thrombocytosis [6]; in c-KIT, WT1, and PTPN11 and acute lymphoblastic leukemia [21]–[23]; and in CEBPA or AML1/RUNX1 and acute myeloid leukemia [22], [24], [25]. The gene discussed is RUNX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.