In addition to the interaction effect of SAT1 (rs3764885) and SMS (rs6654100) described above, one SNP (SMS, rs5951676) made a statistically significant contribution to anxiety disorders (OR = 2.05), independently of the nonsignificant effect of parental anxiety disorders (OR = 1.05) and the significant effect of history of psychopathology (OR = 1.14). This evidence concerns the gene SMS and anxiety disorder.