In spite of the strong evidence suggesting a role for the polyamine system in depression, anxiety, and suicide, with recent evidence indicating direct polyamine dysregulation in brain tissue from individual who died by suicide [27], only a few studies have investigated polyamine-related genes at the genetic level, all of which have focused exclusively on promoter polymorphisms in SAT1, the main rate-limiting enzyme in polyamine catabolism. Here, SAT1 is linked to Anxiety.