For example, it has previously been observed that members of the NF-kappaB, STAT, AP-1 and E2F families [30]–[56], IRF-1 [36], [46], [47], [57], IRF-2 [58], IRF-5 [59], IRF-8 [20], CREB [36], [46], PPARgamma and PPARalpha [60]–[68], SP1 [59], SP3 [69]–[71], RORC [72], NR4A2, TCF2 [73], ETS-1 [74] and FOXP3 [75]–[85] may be implicated in MS and its disease subtypes. The gene discussed is SP3; the disease is myeloid sarcoma.