THBS1 and Dravet syndrome: TSP-1 levels were reduced in both DS astrocyte homogenates and CM, as well as in DS fetal brains, raising the possibility that in DS, TSP-1 deficits could affect critical stages of neuronal development such as neurite outgrowth [28]–[30], [79], neuronal migration [32], or synaptogenesis [20], [80].