The study identified two loci of genome-wide importance, one in strong LD with the major locus at codon 129 and another found in the intergenic region between RARB and THRB. The other genome-wide significant finding in this study highlighted a locus for orally acquired TSEs (vCJD and Kuru), using meta-analysis. The gene discussed is THRB; the disease is variant Creutzfeldt-Jakob disease.