In an attempt to minimise the risk of false negative ER calls from our gene signature methods due to stromal contamination, we have taken advantage of the fact that in ER negative tumours, not only is the set of ER regulated genes down-regulated but a well defined set of epithelial genes, such as FOXC1 and GABRP are overexpressed as well. The gene discussed is FOXC1; the disease is neoplasm.