MC4R and obesity disorder: Moreover, an obesity-risk-allele score, comprising variants in or near the FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF and ETV5 (SFRS10) loci has been tested for an association with birth weight in 7,146 individuals [17] and a modest association with BMI at birth was observed.