In the Manhattan plot (Figure 2C), associations are highlighted corresponding to SNPs located in the genomic vicinity of a number of genes for key inflammatory cytokines crucial in psoriasis The Figure shows that none of the polymorphisms near the major cytokines IL-22, INF-γ, IL-1, IL-17A and IL-6 reached the significance association levels () determined by the GWAS [17]. This evidence concerns the gene IL1A and psoriasis.