These differences translated to differential net accumulation (p<0.003) of MTXPG (NET-PG) with highest accumulation in B-lineage hyperdiploid and B-lineage non-hyperdiploid ALL, followed by t(12;21) [ETV6-RUNX1], T-lineage, and t(1;19) [TCF3-PBX1] ALL (Figure 3B). This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.