TCF3 and acute lymphoblastic leukemia: In addition, there was a significant difference (p<0.0002) in the maximum FPGS activity among the different molecular subtypes of ALL with the highest activity in B-lineage hyperdiploid ALL followed in decreasing order by B-lineage non-hyperdiploid, t(12;21) [ETV6-RUNX1], t(1;19) [TCF3-PBX1], and T-lineage ALL (Figure 3A).