This study of genes associated with Crohn's disease has identified definite genome-wide significant association with AS of SNPs at chromosome 1q32 near KIF21B, and experiment-wise association at five other novel-AS loci including STAT3, IL12B, CDKAL1, LRRK2/MUC19, and at chr13q14. The gene discussed is KIF21B; the disease is Crohn disease.