The results of this study show that the gene prevalence of TLR4 (896) AG and TLR4 (896) G alleles in UTI patients is higher than that in the control group, and the gene prevalence of TLR4 (896) AG and TLR4 (896) G alleles in patients with acute cystitis and urethritis is higher than that in the healthy control and acute pyelonephritis groups. The gene discussed is TLR4; the disease is acute pyelonephritis.