PRKN and Parkinson disease: Two of these genes, PINK1 (PARK6, OMIM #605909, Gene ID: 65018) and parkin (PARK2, OMIM #600116, Gene ID: 5071), are associated with early-onset autosomal recessive PD, in which loss-of-function (LOF) of a single gene product results in the clinical manifestation of Parkinsonism [1], [2].