PINK1 and Parkinson disease: In conclusion, the results of our genetic study demonstrate that the mitochondrial-localized protein PGAM5 modulates the PINK1 pathway in Drosophila. However, further work will be required to determine how PGAM5 regulates the PINK1 pathway at the molecular level, as well as to determine if manipulation of PGAM5 activity might provide a therapeutic advantage in treatment of PINK1-associated PD.