In addition, numbers of FOXP3+ cells were diminished in untreated mice, but significantly increased (comparable to the observed numbers in naïve mice) in treated animals after ileitis induction which correlates with increased concentrations of the anti-inflammatory cytokine IL-10 observed in ileum, MLNs, and spleen at d8 p.i.. This evidence concerns the gene FOXP3 and Crohn ileitis.