TMEM135 and lung adenocarcinoma: TMEM135 was first identified in a lung adenocarcinoma cell line cDNA library,[11] but a recently published paper suggests that TMEM135 might be a critical gene for adipogenesis and osteoblastogenesis.[12] Due to the fact that TMEM135 was found to be phylogenetically highly conserved, we hypothesized that the regulatory feedback circuit to which it belongs, as well as its function, might be equally conserved.