Among the 37 kinase genes gaining activity in PRCa in comparison to healthy prostate there were 22 kinase genes (MASTL, CCRK, NEK6, MAP3K13, DCLK1, CSNK1G3, ATR, SBK1, TESK2, BRSK2, FGFRL1, VRK1, PRKCZ, PKN2, LMTK3, CDK3, NRBP2, MAP4K3, MARK1, MARK4, TSSK4, ENSG00000121388) without previous association to PRCa based on the Pubgene [52]. This evidence concerns the gene PKN2 and pure red-cell aplasia.