Figure 1G shows that, prolonged exposure to HFD induced a 38% lower serum adiponectin level in DIO than in lean mice (P = 0.0004), whereas this level was remarkably increased (P<0.0001) by Boc5 to the normal range observed in SCD fed controls (11.7 μg/ml in 3 mg group vs. 11.9 μg/ml in SCD group). Although pair-fed mice displayed certain degree of improved circulating leptin and adiponectin concentrations, the effects were relatively marginal and not as pronounced as seen in 3 mg Boc5-treated animals (P = 0.0003 for leptin and P = 0.0444 for adiponectin; Figures 1F and 1G). The gene discussed is LEP; the disease is Schnyder corneal dystrophy.