IL6 and Sepsis: In addition, skeletal muscle and adipose tissue contribute to IL-6 expression during sepsis [45], [46], [47], and since the anti-inflammatory effect of insulin is mediated through the PI3K pathway [14], [15], [18], we can speculate that the restoration of this pathway in the insulin-dependent tissues, induced by atorvastatin in septic animals, may have also contributed to the anti-inflammatory effect of this drug.