CLU and neoplasm: Treatment of the human cell line, retinal pigment epithelial cells (ARPE-19) with HDACI valproic acid or TSA and the demethylating agent 5-aza-2’-deoxycytidine resulted in increased clusterin mRNA and protein levels [75], further demonstrating that clusterin expression is epigentically regulated and may play a vital role in neo-angiogenesis in a tumor setting.