To confirm the effects of SUN N8075 on motor dysfunction and the survival of the familiar ALS model, we used two types of transgenic animals overexpressing mutated human SOD1 genes: transgenic mice overexpressing mutated (glycine to alanine in position 93) human SOD1 (G93A) [16] and transgenic rats overexpressing mutated (histidine to arginine in position 46) human SOD1 (H46R) [17]. Here, SOD1 is linked to amyotrophic lateral sclerosis.