However, there is a paper reporting that the strong expression of phosphorylation of another translation initiation factor eIF2α observed in subpopulations of neurons bearing neurofibrillary tangles or pretangles in the postmortem brain from patients with Alzheimer's disease [59], suggesting that factors linked with tau deposition might regulate protein synthesis throughout eIF2α phosphorylation in certain neurons of Alzheimer's disease. This evidence concerns the gene EIF2A and early-onset autosomal dominant Alzheimer disease.