ARHGDIA and cancer: Among the newly identified proteins (see Table 2), nucleotide diphosphate kinase A, annexin A3, Rho-GDP-dissociation inhibitor 1, beta-microseminoprotein, chloride intracellular channel protein 1, protein disulfide-isomerase, calreticulin, peroxiredoxin-2, alpha-1-acid glycoprotein 1 and IgG Fc-binding protein are considered clinically interesting as they have been previously associated with cancer and other diseases [52–61].