MYOC and glaucoma: Thus it can be surmised that glaucoma results either due to insufficient levels of secreted MYOC or compromised TM cell function caused by congestion of the TM secretory pathway.[45] MYOC is also known to be associated with the mitochondrial pathway and it has been shown that overexpression of MYOC carrying P370L mutation results in higher endogenous ROS (reactive oxygen species) production.