JUP and open-angle glaucoma: Based on this approach, Thorleifsson et al., (2007) identified three SNPs (rs1048661, rs3825942 and rs2165241) in lysyl oxidase-like protein 1 (LOXL1) gene on Chromosome 15q22 that were significantly associated with XFS/XFG.[88] Due to the association of POAG and XFS, further analysis of these SNPs in POAG in other populations revealed no significant association in POAG, PACG and PG indicating their exclusive involvement with XFS/XFG only.[89]