Later Myocilin/TIGR (accession numbers: Nucleotide AH006047, Protein NP_000252) on this locus was characterized to be causative for POAG.[33] This gene is also termed as trabecular meshwork-induced glucocorticoid receptor (TIGR) as it overexpresses due to the induction of glucocorticoid to the cells. Here, MYOC is linked to open-angle glaucoma.