Common polymorphisms in MYOC, OPTN and APOE were identified that might interactively contribute to POAG.[50] Some studies also observed interaction between Noelin 2 (OLFM2/317A) and OPTN (OPTN/412A) and the OLFM2/1281T and OPTN/412A SNPs with OAG with elevated IOP.[142]. This evidence concerns the gene OPTN and open-angle glaucoma.