CYP1B1 and open-angle glaucoma: Based on these observations, it was suggested that PCG and JOAG are allelic variants of CYP1B1. It was also hypothesized that CYP1B1 and MYOC might act through a common biochemical pathway with CYP1B1 acting as a modifier for MYOC.[73] Later the association of CYP1B1 was reported across different populations ranging from 2.2%-23.3% with JOAG, POAG and PACG [Table 4].