However, the region on chromosome 9p21 associated with CAD is defined by two flanking recombination hotspots and contains the coding sequences of genes CDKN2A and CDKN2B. Thus a large number of SNPs in this region show highly significant association with CAD and the causally responsible variant and the related mechanism remains to be identified. The gene discussed is CDKN2A; the disease is coronary artery disorder.