GSTM1 and hemoglobinopathy: The laboratory diagnosis of thalassaemias and other haemoglobinopathies can be achieved by a step-wise approach starting with a detailed clinical history, thorough haematologic evaluation [including haemoglobin level, complete blood count (CBC), reticulocyte count, and red blood cell (RBC) morphology], protein based analytic methods [alkaline and acid Hb-electrophoresis, isoelectric focusing (IEF) and high performance liquid chromatography (HPLC)] and nucleic acid based methods [such as polymerase chain reaction (PCR), reverse transcriptase (RT)-PCR, and sequencing of genomic DNA]1, 2.