BCL6 and infection: Bcl-6 down-regulation ofthe DDR mitigates the consequences of centroblast hyper-proliferation in thegerminal center (Ranuncolo et al., 2007),while EBV potently suppresses Bcl-6 early after infection leaving DDRcheckpoints intact (Siemer et al., 2008).In vivo, an EBV-induced hyper-proliferative period afterprimary infection may promote extra-follicular B cell maturation or driveEBV-infected naïve B cells into GCs.