The recently established Hodgkin cell line U-HO1, derived from a patient with primary refractory HL of nodular sclerosis subtype, is EBV negative, expresses CD15 together with CD30 and has a clonal non-functional VDJ-heavy gene rearrangement (Mader et al., 2007). The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.