The WHHL rabbit, therefore, demonstrates metabolic and clinical abnormalities similar to those in patients with FH and may be a more authentic FH model than the LDLR-/- or ApoE-/- mouse models [80] where the raised plasma cholesterol levels (225 ± 27 mg/dl) are lower unless the animals are subjected to a high cholesterol diet. This evidence concerns the gene LDLR and familial hyperaldosteronism.