CASP3 and cancer: Surprisingly, however, apoptosis studies designed following pharmacological inhibition of Akt (with Akt Inhibitor VIII) was unable to sensitize the cancer cells to TRG-induced apoptosis in the presence of serum (Figure 6A, compare PARP and Caspase-3 cleavage, lanes 5 and 6), despite complete inhibition of the phosphorylation of Akt downstream targets FoxO1Thr24/FoxO3aThr32 (pFoxO1/3a panel).