Such genetic synergy suggests that the pathways emanating from the two genes intersect downstream, supporting the idea that only a subset of all possible pathways are involved in a tumor harboring a mutation in Apc. We hypothesize that these mutations have distinct synergistic effects on the cancer phenotype, such that the activities of these networks are greatly associated with the measured downstream changes in the proteome of the intestine. The gene discussed is APC; the disease is neoplasm.