Fluoxetine (in-label doses for depression and anxiety disorders range between 20-80 mg/day) is an SSRI antidepressant stimulating 5-HT2A postsynaptic receptors and desensitising 1A receptors; it also acts as a 5-HT2C antagonist, increasing norepinephrine and dopamine neurotransmission at the prefrontal cortex [13]. Here, HTR2C is linked to major depressive disorder.