Highly encouraging results have been achieved with iPSCs from skin fibroblasts, differentiated to insulin-secreting pancreatic islets [54]; in lateral amyotrophic sclerosis (Lou Gehrig disease) [55]; and in many other conditions such as adenosine deaminase deficiency combined with severe immunodeficiency, Shwachman-Bodian-Diamond syndrome, type III Gaucher disease, Duchenne and Becker muscular dystrophy, Parkinson and Huntington disease, diabetes mellitus, or Down syndrome [56]. The gene discussed is INS; the disease is amyotrophic lateral sclerosis.