Our results differ with those obtained in a recent study conducted by Leidl et al [26], where the correlation of the number of CD4 T cells with the IFN-γ released in QFN-G-IT was positive (Spearman's rho = 0.38; p = 0.0001), and constant with the number of ESAT-6 and CFP-10 specific T cells in T-SPOT.TB (Spearman's rho = 0.03; p = 0.77 and Spearman's rho = 0.13; p = 0.21, respectively). This evidence concerns the gene CD4 and tuberculosis.