IRS1 and Insulin resistance: Among the 8 type 2 diabetes effector proteins which establish direct relationships, there are 7 from the insulin resistance pathway (SLC2A4, CBL, PRKCA, NFKB1, IRS1, PPARGC1A and AKT3) and 1 from the insufficient insulin production pathway (GH1), see details of the proteins involved in Table 2.