In women with PCOS (n = 200), serum lipocalin-2 levels were negatively correlated with the QUICKI (r = -0.265, p < 0.001), the glucose/insulin ratio (r = -0.245, p < 0.001) and plasma SHBG levels (r = -0.152, p = 0.031) and positively correlated with the waist/hip ratio (r = 0.348, p < 0.001), W (r = 0.343, p < 0.001), BMI (r = 0.314, p < 0.001), HOMA-IR (r = 0.265, p < 0.001) and plasma insulin (r = 0.254, p < 0.001) and glucose levels (r = 0.162, p = 0.002). This evidence concerns the gene SHBG and polycystic ovary syndrome.