Additional work is required to determine the molecular basis to PEA3-driven oesophageal cancer cell proliferation but MMP-1 expression is unlikely to account for the altered proliferation as PEA3 siRNA construct B does not significantly reduce MMP-1 levels (Figure 2G) but it does profoundly affects proliferation (Figure 4E). This evidence concerns the gene MMP1 and carcinoma of esophagus.