FOXO1 and rhabdomyosarcoma: In the context of human Rhabdomyosarcomas, which result from a chromosomal translocation leading to the expression of a fusion protein, PAX3-FKHR or PAX7-FKHR in which the PAX DNA binding domain is followed by the strong transcriptional activation domain of the FOXO1A (FKHR) factor, a number of microarray screens have been performed on cultured cells (for review see [15]).