Several proinflammatory cytokines, acute phase-reactants and cell adhesion molecules seem to play a role in low grade inflammation, and today there is substantial evidence supporting the role of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) among others as cardiovascular risk markers and participants in the pathogenesis of obesity, T2D and cardiovascular disease (CVD) [1-4]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.