Interestingly, another work at the same time demonstrated that c-Myc could induce the expression of miR-17-92 and E2F1 growth factor, and that the miR-17-92 could inhibit the overexpression of E2F1; therefore, the miR-17-92 cluster could act as either an oncogene or tumor suppressor, depending on the context and cellular environment [17]. This evidence concerns the gene E2F1 and neoplasm.