In this report, we expanded upon the results of the GWAS discovery of the LIPC gene by evaluating the association between the LIPC genetic variant and other genes related to advanced AMD, exploring the relationship between this gene and the two distinct advanced “dry and wet” phenotypes, and assessing LIPC gene-environment associations and interactions with demographic, personal and lifestyle factors. The gene discussed is LIPC; the disease is age-related macular degeneration.