IL4 and atopic eczema: Indeed, antioxidant defense impairment in atopic dermatitis has been confirmed in a study reporting that N-acetyl cystein (NAC) was able to down-regulate Th2-secreted-cytokines, such as IL-4, IL-5 with a subsequent over-activation of the Th1 response, suggesting that in Th2 related diseases, such as atopic dermatitis, NAC might serve as a possible therapeutic agent [40].