CFH and age-related macular degeneration: The discovery of the strongest associations of AMD with the variants of complement factor H (CFH; OMIM 134370) [10-13] and ARMS2/HTRA1 (age-related maculopathy susceptibility 2, OMIM 611313; the high temperature requirement factor A1, OMIM: 602194) [14-17] has led to new hypotheses regarding the pathogenesis of this disease.