MIP and autosomal dominant cataract: To date, seven mutations in the MIP gene have been identified from seven unrelated human families; five missense mutations (T138R, E134G, R33C, R233K, and V107I) [5-8], one deletion mutation causing a frameshift that alters 41 of 45 subsequent amino acids and creates a premature stop codon (G213VfsX45) [9], and one splice-site mutation causing autosomal dominant congenital cataract (ADCC) with “snail-like” phenotype in a large Chinese family (our laboratory’s recently reported finding, c.607–1G>A) [10].