It is also of note that Bcl-2 has recently been reported as a powerful independent predictor of good prognosis in a study of >11 000 invasive breast carcinomas (Dawson et al, 2010), and this further suggests that the clustering of DCIS into subgroups defined in part by Bcl-2 may be of functional and clinical importance. The gene discussed is BCL2; the disease is invasive breast carcinoma.