Such mutations have been documented in all subtypes of melanoma (Curtin et al, 2005), including cutaneous (50–60% BRAF, 15% NRAS and 17% CKIT chronic sun damage), mucosal (11% BRAF, 5% NRAS and 21% CKIT) and uveal (50% GNAQ) melanomas. The gene discussed is BRAF; the disease is melanoma.