The frequency of BRAF mutation in primary melanomas ranges from 36 to 45% (Curtin et al, 2005; Liu et al, 2007; Thomas et al, 2007) and 42–55% in metastatic melanoma (Houben et al, 2004; Ugurel et al, 2007; Long et al, 2010). The gene discussed is BRAF; the disease is melanoma.